Regenerative design aims to reverse environmental degradation and generate net positive impact by developing systems that are mutually beneficial and co-evolving for natural and social components of the living environment. As a regenerative approach is not only related to design but also to humans and their activities, this chapter reveals the necessity to establish a new interconnectedness between design principles of environmental regeneration and a tendency to intensify positive environmental effects on humans. This paper identifies biological entities as significant agents in bringing the human perspective closer to the regenerative approach and accordingly explores their application in design by analysing characteristics and benefits of utilisation, and by providing different experimental examples developed by scientists, designers, and the members of academic community. In particular, this work studies design solutions based on the biological principles of growth and finally focuses on how building-integrated plant systems contribute to regeneration.